In a large mixing bowl, add all ingredients (except pie crust) and mix until thoroughly combined.
Pour the mix into the pie shell and bake for 10 minutes at 450 degrees. Then lower heat to 350 degrees and continue baking for approximately 50 more minutes.
Remove pie from heat, and allow it to cool for 5 mnutes prior to serving.
Notes
Adjust the amount of cayenne to your liking. This recipe as it stands (1/2 teaspoon cayenne pepper powder) provides considerable spiciness to the pumpkin pie. If you're baking for a family/holiday meal where there's a wide variety of heat tolerances at the table, we recommend lowering the amount to 1/4 teaspoon. The same if you tend to like milder "warming" spiciness.